Motor Neuroscience and Neurorehabilitation Laboratory

At the Motor Neuroscience & Neurorehabilitation Laboratory (MoNeL), our mission is to achieve sustainable recovery for individuals with neurological impairments. Our research program, "Restoring Post-Stroke Locomotion: From Biomechanical Modulation to Neural Stimulation, and Towards their Synergy," seeks to ensure that every individual can remain "Upright Without Falling."

To achieve this vision, our research is built on three core pillars:

1. UNDERSTAND: Biomechanical & Neural Mechanisms

We investigate the fundamental neurophysiological and biomechanical mechanisms underlying impaired motor control and motor learning. By focusing on individuals with stroke and spinal cord injury, we aim to decode how neurological injuries disrupt the synergy between the brain, spinal cord, and musculoskeletal system.

2. INNOVATE: Synergistic Modulation (Mechanical + Neural)

We develop novel rehabilitation tools and targeted neuromodulation protocols. Our laboratory specializes in innovating the synergy between precision biomechanics  and targeted spinal stimulation to retrain the nervous system more effectively.

3. RESTORE: Real-world Mobility & Independence

Our ultimate goal is to translate these mechanisms into scalable clinical solutions that restore functional mobility. By identifying the behavioral and neural adaptations that occur in response to our interventions, we strive to improve walking, balance, and independence in the real world.

Our Infrastructure & Methodology

To address these complex goals, the MoNeL combines advanced behavioral, biomechanical, and neurophysiological analyses. Our interdisciplinary approach utilizes a premier research platform at UH, including:

• Precision Biomechanics: Instrumented dual-belt treadmills (Bertec FIT) and specialized perturbation systems (BalanceTutor) for high-precision movement analysis.

• Targeted Neuromodulation: Constant-current stimulators (Digitimer DS8R) for transcutaneous spinal stimulation (TSS) to modulate neural excitability.

• Comprehensive Neural/Mechanical Sensing: High-density wireless EMG (Delsys), EEG, and Inertial Measurement Units (Xsens IMU) for real-time synchronization of neural and mechanical data.